We are pleased to announce the publication of our latest research article in the journal Cancers, titled “γδ T Cells Are Significantly Impacted by CLL Burden but Only Mildly Influenced by M-MDSCs.”
In this study, we investigated the impact of chronic lymphocytic leukemia (CLL) on γδ T cells and hypothesized that monocytic myeloid-derived suppressor cells (M-MDSCs) might drive these changes. However, our in vitro experiments demonstrated that while γδ T cells are markedly influenced by the overall CLL burden, the direct impact of M-MDSCs is minimal and does not fully explain the observed alterations in γδ T cells in CLL patients.
These findings provide new insights into the tumor microenvironment of CLL and raise further questions about the mechanisms affecting γδ T cell function. The full article is available here.
